2 Small-Cap Shares With Substantial Upside; Raymond James Says ‘Purchase’


Let’s discuss a bit about return potential, and small-cap shares. The 2 attributes are associated, and continuously supply traders a high-quality mixture of risk-reward ratio to emphasise the previous. It’s the essential arithmetic behind discovering a strong return potential. A small cap inventory, one with a market worth decrease than $2 billion, will normally function a comparatively low share value – and when share value is low, even a small acquire in absolute phrases will shortly translate right into a high-percentage return.

A few of at the moment’s tech giants are prime examples of the phenomenon. Apple, with a present market cap nicely north of $2 trillion, was a plucky little small-cap with a share value of $1.10 again within the late Eighties, and Amazon, with its famously excessive 4-digit share value, bought for lower than $10 per share 20 years in the past. Lengthy-term appreciation has labored its magic.

Not each inventory goes to show into the subsequent tech big, after all. However excessive returns are on the market, and the most important ‘trick’ for an investor to be taught is the place to search out that prime potential. We’ve take a primary step, utilizing the TipRanks platform to lookup a pair of small-cap shares with low share value and a excessive upside – in truth, in line with Raymond James analyst Dane Leone each of them are prone to double or higher within the coming 12 months. Let’s take a better look.

Curis (CRIS)

We’ll begin with Curis, a small-cap biotech with each an authorized drug available on the market and an lively growth pipeline. Curis is targeted on anti-cancer analysis, aiming to create modern, first-in-class therapeutic brokers for the therapy of varied cancers. The corporate’s authorized drug, Erivedge, is authorized to be used in sufferers with basal cell carcinoma, a typical pores and skin most cancers, within the US and the EU. The drug is present process commercialization by Roche and Genentech, and Curis receives royalty earnings below the license agreements.

Turning to the pipeline, the corporate’s predominant drug candidate is CA-4948, an IRAK4 inhibitor and a possible therapy for hematologic malignancies. The drug candidate is present process a number of Part 1 medical trials, and has demonstrated efficacy, outlined as anti-tumor exercise, in non-Hodgkin’s lymphoma, acute myeloid leukemia and myelodysplastic syndromes. Earlier this month, the corporate launched further pre-clinical knowledge displaying that CA-4948 is ready to cross the blood-brain barrier, which helps a push to check the drug in sufferers with major central nervous system lymphoma.

Overlaying this inventory for Raymond James, analyst Dane Leone lays out the upbeat prospects for the corporate.

“Our funding thesis is based on three key factors: 1) we consider that there’s a vital market alternative in late line AML/MDS for sufferers harboring U2AF1 and SF3B1 mutations which CA-4948 is positioned to handle; 2) we’re optimistic about anecdotal Part 1 medical exercise of CA-4948 in FLT3 mutant AML/MDS, a well-established druggable goal; and three) the protection profile of CA-4948 monotherapy helps mixture potential with present normal of take care of AML/MDS,” Leone famous.

Leone provides, in regard to the market alternative, “We at present forecast $370M gross sales of CA-4948 inside AML throughout 2034, based mostly upon what we take into account to be a decrease certain of potential drug utilization, which we predict is acceptable given the encouraging however largely anecdotal medical knowledge generated to this point.”

In step with these feedback, the analyst provides CRIS an Outperform (i.e. Purchase) score and a $15 value goal. Buyers may very well be sitting on positive factors of ~107%, ought to Leone’s forecast play out over the approaching months. (To look at Leone’s observe report, click on right here)

General, the inventory has a Sturdy Purchase score from the analyst consensus, and it’s unanimous, based mostly on 3 latest constructive critiques. The shares are priced at $7.25 and the $19 common value goal is much more bullish than the Raymond James view, implying a strong upside of 162% for the subsequent 12 months. (See Curis inventory forecast on TipRanks)

Ocular Therapeutix (OCUL)

The second small-cap inventory we’ll take a look at is Ocular Therapeutix. As its identify suggests, Ocular is a biopharma analysis agency engaged on new therapies for eye circumstances. The corporate’s growth focus is predicated on a proprietary know-how, a bioresorbable hydrogel-based formulation. This gel is designed to ship therapeutic brokers on to the attention with out drops or injections.

Ocular has two authorized medicine available on the market, Dextenza and ReSure. The primary is indicated for post-surgical ache and irritation of the eyes, and the second is an incision sealant to comply with cataract surgical procedure. Earlier this month, Ocular introduced that Dextenza had acquired FDA approval of a Supplemental New Drug Software, to be used treating itching symptomatic of allergic conjunctivitis.

The corporate reported $11.1 million in gross sales of Dextenza for 2Q21, or 94% of the entire $11.7 million in income. The remaining $600K in income was attributed to gross sales of ReSure. Gross sales of each medicine had been up considerably from the year-ago quarter; Dextenza gross sales grew 692% year-over-year, whereas ReSure gross sales tripled.

Ocular additionally maintains an lively growth pipeline, with its main candidate, OTX-CSI, present process a Part 2 medical trial within the therapy of dry eye illness. The Part 2 examine has accomplished enrollment and prime line knowledge is anticipated throughout this fourth quarter interval of 2021.

Forward of the upcoming top-line outcomes from OTX-CSI, Raymond James’ Dane Leone reiterated his Sturdy Purchase score on OCUL together with a $29 value goal. Ought to his thesis play out, a possible upside of 159% may very well be within the playing cards.

“The Part 2 is anticipated to make clear the trail ahead in the direction of registrational research in dry eye. Primarily based upon the potential twin mechanism of motion (punctal plug pluscyclosporin), medical differentiation will probably be based mostly upon two major components 1) improve in tear manufacturing utilizing the Schirmer rating, and a pair of) tolerability versus drop formulation of cyclosporin (Restasis). We don’t at present embody OTX-CSI inside our monetary forecasts for OCUL, however given the pretty clear medical hurdles required to run a profitable dry eye illness drug growth program, we predict that the Part 2 outcomes for OTX-CSI may very well be an vital worth creating occasion for the pipeline,” Leone opined.

General, this inventory additionally will get a Sturdy Purchase score from the analyst consensus, and like Curis above, it’s unanimous – on this case, based mostly on 4 constructive analyst critiques. The inventory is promoting for $11.19 and has a median value goal of $27, suggesting ~141% upside potential from that degree. (See OCUL inventory forecast on TipRanks)

To seek out good concepts for small-cap shares buying and selling at enticing valuations, go to TipRanks’ Finest Shares to Purchase, a newly launched software that unites all of TipRanks’ fairness insights.

Disclaimer: The opinions expressed on this article are solely these of the featured analyst. The content material is meant for use for informational functions solely. It is rather vital to do your individual evaluation earlier than making any funding.

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